I'm kinda hoping they come out with it in .45ACP. .40 is ok I'm sure but it's not a round I'm shooting currently.
I think it has a lot of merit for a CC gun. The big bore is appealing in the short barrel since you aren't as dependant on expansion form that stubby tube for stopping power and, IMO at least, .45 recoil is not that bad. More pleasant than the .357 mag's I normaly shoot in a snub revolver anyway.
Plus, the moon clips allow a faster reload and unload than speedloaders do. When you get home at night too it's easier to drop a loaded moon clip and then re-insert it in the morning than it is to do so with loose rounds. Not a big deal I realize but it is a convenience issue.
And, a moon clip of stubby .45ACP rounds is smaller and flatter to carry than a speedloader of .44 Special or .45 Colt like with the other Taurus big bore snubbys. I suppose there is some chance of the clips getting bent in your pocket or what not but, assuming the clips are well made (like the 9mm ones for the Ruger SP-101 or S&W 940), it shouldn't be that big of a deal.
Finally for the LEO who wants the reliability of a revolver as a backup or off duty gun the new Taurus allows him the option of sticking with a gun chambered for the same round as his service pistol.
I like the idea personally and if they do come out with a .45ACP version I'll probably jump on it. I've been looking for a big bore snub for a while now but just haven't found the right one. That .40 is close but not quite it yet