As stated by another poster, the difference is marked between SA and DA shooting. The hump at the top of the grips on Smith, Colt and Ruger DA's was designed to prevent the gun shifting position in your hand during recoil. In fact, the recoil movement in DA guns is much more of a straight back movement at first. Personally, I find them much more uncomfortable with truly heavy loads than the SA models which conform to the Colt Single Action Army style.
SA's in comparison, roll up in your grip, pointing skyward in heavy recoil making them a little softer in feel than the DA's. I do find that some rap my middle knuckle as they turn upward, and the Ruger's, especially, have a sharp edge at the rear of the frame that cuts into the web of my hand.
Elmer Keith, that noted curmudgeon of heavy loaded handguns, noted that repeat shots with a heavily loaded SA were not as difficult to master as some would have us believe since the skyward, rolling movement actually made thumbing the hammer back that much easier. He also believed that that same movement softened the felt recoil. I find that to be true as well.
Since I rarely use the DA feature of my Smith .44's and .41's with heavy loads, it's a mute point for me. IN SA, two-handed use, my weak gripping hand (left one in my case), does the cocking of the hammer in both types. But I do find recoil more comfortable with the Single Action Army grip style in Colt and Ruger guns.
As to the new, so-called, "Cheese Grater" black plastic grips on Ruger's SA's, I find them usable in moderate loads, and not particularly uncomfortable. For the heavy load end of the spectrum, a thicker grip profile feels better to me. That style, known as "Gunfighter" grips by some makers is a better choice. I've made my own for many of my single actions of both makes. They're not particularly hard to do, given a small amount of tool acumen, and you can spend a nice Saturday morning carving to your satisfaction.
Here's a pic of my version of the "gunfighter" style, done in rosewood for my 4-5/8" bbl'd Ruger Stainless, Flat Top, .44 Special.
HTH's Rod.