Stagpanther,
With handguns of either the rotary or linear fed kind, I've found getting the gun accurized, followed by bullet choice followed by charge choice does the most for accuracy. Beyond that, the specific gun needs to be known to do much better. For example, in a 1911, seating cast bullets out so the cartridge seat is bullet contact with the lands has cut target load group size by up to 40% for me. However, in the same gun, it made no difference to how jacketed bullets performed. But in a revolver, that's useless information regardless of bullet type. In a revolver, getting all the chamber throats to a uniform diameter at least 0.0015" over groove diameter and timed to line chambers up with the center of the bore seemed to be most important to mechanical accuracy with cast bullets. Good trigger work has proven to be very important to the operator being able to sandbag good groups.
A general observation I would make is that, with the exception of single-shot handguns, a handgun that will group 2 MOA 50 yards is considered the match accuracy equivalent of a rifle that will group ½ MOA at 100 yards. About a 4:1 accuracy expectation from self-loading and revolving handguns for match shooting. Mostly, you can't see the variation caused by mixed brass, exact bullet jump and other factors that affect load tuning in a rifle in a 2 MOA group, so a lot of that detail just can't be usefully applied to pistol and revolver loads. You simply get a lot more mileage out of the larger load factors, like bullet choice. Even in an exceptionally tight shooting gun like my Redhawk, I can't see signs of the flat spots in an Audette ladder that you get with a rifle, as revealed by Varmint Al's animation showing the exaggerated barrel bending in a rifle with a barrel tuner. I think the shorter barrel is just too rigid to bend appreciably under the upswing caused by recoil. Too many other movement factors are dominating the precision limits. Keep in mind the moment of inertia for a rotation on a horizontal axis perpendicular to the bore axis, where the length of the barrel is the radius of the recoil elevated mass, will go up as the square of the length of that radius (the length of the barrel). So a 4-inch revolver barrel, subjected to the same amount of recoil lifting force as a 24" rifle barrel with the same OD and same bore dimensions would see only 1/36 of the barrel bending at the anchored receiver end that 24-inch barrel would. That explains a lot about why the muzzle swing is MIA from group analysis for the revolver.