Magnum: My wild guess,stability is in part a function of RPM. At 2500 fps +,it takes at the veryleast a 1 in 9 twist to stabilize a 75 gr HPBT,and that is marginal. A 1 in 8 twist is more reliable. When you cut the velocity to less than half,you cut the RPM's,too.
As far as the subsonic .223's...Do whatever makes you happy. Your opinion is as good as mine.
IMO,the 60 gr Aguila subsonic 22 LR load through a twist tailored to this bullet would be my choice.There were 10-22 barrels offered (aftermarket..Clerke maybe) for this application.
It has been my experience that for purposes of not being annoying or attracting much attention,any subsonic 22 LR is pretty quiet out of a rifle even without a suppressor.
IMO,if a person really wants to develop an effective suppressed AR,the .300 Blackout is probably a better choice.