I have loaded for .308, .45 ACP, .223, and 7.35 mm, but most of my loading experience involves the .45 Colt and I really haven't noticed a great deal of difference in the accuracy of the various loads I have done. I have found just the opposite to be true in regards to my wife's Sig P238 .380 ACP. After trying three loads which looked more like a shotgun pattern, I finally found one that I was pleased with. The case, primer and bullet and OAL were the same on all four loads. Only the powder, and of course grains of powder, was different. I can understand that one powder might be somewhat more accurate than another, but is it common for some loads to be downright terrible, and if so, what causes it?