considering a 357 magnum revolver with 3 to 6 inch barrel lengths in mind.
I didn't see your most recent post until after my most recent post.
There is a big difference between a 357 with a 3" bbl, compared to a 6" bbl. They are quite different animals. I have S&W 686's in 3", 4", & 8-3/8"; plus, a Python in 6". The way they behave with the same ammo is quite different.
What will be the primary purpose for this gun? (carry? home defense? hunting?) Any special considerations? (arthritis? the shakes, etc.)
I carry my 3" 686. I use my 4" in competition. I punch a lot of holes in paper (shoot recreationally) with both. My other two 357s spend a lot of time keeping each-other company in a safe.
So for me, I'm shooting relatively shorter barreled 357 Mags. That is a major factor in my powder selection. All else being equal, loading with a shorter barreled gun means shifting your powder choice toward the faster stuff. Bullet weight is also a major factor. Lighter bullets shift your powder choice toward the faster stuff too.
Although I shoot with 3" & 4" bbl guns, I tend toward heavier bullets. I prefer 158's (but still shoot my share of 125's).
So with 158's, I usually use HS-6 or Power Pistol. If I'm going a little hotter, I use AA#7. I do use 2400 a little bit, but it's kind of a novelty thing; as the report, flash, & recoil are excessive (in my opinion). And the 2400-loaded rounds almost never see the 3" bbl gun - it's just silliness with such a short barrel.
With 125's, my powder selection shifts toward faster stuff - albeit with some overlap. I usually use AA#5, Unique, or Power Pistol. But never HS-6, AA#7, or especially, 2400. If I'm taking a longer barreled gun to the range, then yes, maybe I'll load up some 125's with slower stuff; as the longer barrel will tame the report, flash, & recoil - and convert it to velocity
That just kind of gives you a feel of one long-time (32 years) loader's approach. I'm not saying you must use these powders for those bullet weights. I'm just demonstrating how it's typically approached.