H4895 is known to let you go lower than most. IIRC, Hodgdon says 60% of maximum listed loads can be made using it. I would not go below about 60% case fill, though, just based on experience.
For light loads,
Trail Boss loads are great and seem to group well out to 100 yards which will give you a baseline zero for a new scope, for example. However, rifle barrels are subject to recoil-induced flexing and slight elastic barrel deformation by high pressure and the timing of getting the bullet to the muzzle. As a result, what zeros with a mild load can be off several inches when the actual load is used. So, after zeroing with a mild load, you want to at least test a few of the actual full power loads you intend to use to look for zero displacement caused by those other factors. The bottom line is the only way to reliably zero for a load is with the load itself at a range long enough to see those load dynamics at work. 100 yards is sort of a minimum for seeing that clearly, IME, but you could try at a shorter range.
25 yard sighting assumes certain factors about the load velocity and the height of the site above the bore line that may or may not apply in your particular case. Check the out on a ballistic trajectory program like the
free ones at the JBM ballistics site. I've had some rifles that gave me a 100 yard zero with anywhere from 18 to 32 yard targets, depending on actual setup. If, for example, you want a 200 yard zero for deer hunting, run that zero with your bullet and expected velocity in the software and see where it first crosses zero, then set up your rough-in and check sighting at that range.