What is the intended purpose? IMO both are terrific pistols.
CZ Shadow 2, which is designed as competition pistol, will most likely have an advantage at the range being considerably heavier by 12 ounces, almost an inch longer, and a lighter trigger.
IMO P226 being a combat pistol would be a better all around pistol if self defense use is a consideration too. P226 has firing pin block that the CZ Shadow 2 lacks, has a decocker, though a bit large CCW is a possibility, and the slide gripping area is much larger for easier manipulation of the slide.