Gunslinger's solution might work for you. I've heard several positive comments. It might work even better with a smaller gun. When you say "large frame" I usually think of the large N-frame S&Ws or similar.
Also, autos (generally) are flatter and easier to conceal.
The other aspect to consider is wardrobe. A neat, tucked in dress style makes for a difficult concealment carry without a jacket or other covering garment. Consider slightly oversized shirts, etc. of the heaviest feasibe fabric - preferably darker and/or patterned. That helps avoid blatent printing.
A final consideration, try to find the best combination you can - and then wear it a lot until you get used to it. Most folks won't see a gun unless they are looking for a gun. If you are self-counscious (sp?) and frequently adjust your clothing or have other mannerisms that draw attention to the fact that you are carrying a gun - you're a lot more likely to be "made".
I sympathize with your problem. I'm a scrawney old geezer, but fortunately (?) I can dress very informally (or as my wife says "Like a slob") and that makes concealment much easier.
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Jim Fox