My wrist was injured in an on-duty altercation several years ago. Surgery helped but couldn't really fix it. So now it's arthritic, etc. Prior to the injury I shot 44 mags and my .454 Casull,etc. At the risk of having my man card pulled, I admit that after shooting "real" 10MM ammo or .357 now, my wrist will be sore for a couple days. Luckily, I ordered a .45 ACP cylinder for my .454. I haven't fired .44 Mag in a handgun, or .454, since the incident. I am not concerened, that's just the way it is. I continue to enoy shooting everything up through 45 ACP, 10MM and .357, and will continue ......ymmv