While on the subject of Single Action grip profiles, several years ago I set up some Ruger Blackhawks, plus one Vaquero. I had each one with a 4 5/8" barrel and a 7 1/2" barrel and having the Bisley grip frame, the Super Blackhawk grip frame, and the XR3-RED grip frame. These were in .45 Colt and I used mild target rounds as well as snortin' fire breathing loads. I fired these for fast Single Action shooting as well as long range shooting.
My preference for fast handling was the standard Blackhawk grip profile, the XR3-RED (I did not have an XR3 to set up) while the Super Blackhawk (Elmer Keith called it the Dragoon grip frame) was best for heavy loads. In my experience, the Bisley profile came in last. It whacked my knuckle severely, and pointed dreadfully in fast shooting. With my heaviest loads, the XR3-RED rotated so the point that the sharp edges of the cylinder frame dug into the web of my hand.
Frankly, in my handling of my guns, I can find only slight difference between the XR3 and the XR3-RED grips. Oh, I can feel the difference, but it seems to have no effect on my shooting. The only Blackhawk I have now with the XR3 frame is a New Model Flat Top .44 Special.
Some of my "test" set-ups:
Bisley 4 5/8":
"Super" Blackhawk, 4 5/8":
"Super"Blackhawk, 7 1/2":
All above .45 Colt.
Bob Wright