Christopher,
The N frame is perceptibly larger than the L. For me personally, depending on the grip size, the various N frames may have too long a "reach" to the trigger.
There are several factors here. One is that, in the past, all the N frames were square butted and had either too big ("Target") stocks or too small ("magna") grips. Today they are all round butts and that helps me some, but the style of grip being used is still the most important thing. I think if you can handle and L frame, you can, with the proper set of grips handle the N. I don't know about the present configuration of the round butt of the N frame, but, in the past, I bought several revolvers which were N framed, but designated "K frame round butt." If that is the configuration they are using now, you will probably be okay, as the K and L butts are the same. Again, I think the secret lies in the proper grip selection, though the frame size will cause a slightly different reach. Many aftermarket grip configurations are available.
BTW, the "625" is the designation for the .45 calibers, both ACP and .45 Colt. If you are going for the .45 ACP version, I think that is a fine choice, since I seem to remember from your previous posts that this will be your first handgun. The .45 ACP cartridge is much more versatile in terms of factory ammo offerings than the .45 Colt (sometimes called "long Colt"). Hope this helps.