My son, who is now 26, has a S&W 625 that I purchased for him when he was a teenager, so roughly 10 years ago. We've fired it a lot with both 45ACP and 45 Auto Rim, and the former both without and with full and half-moon clips. I don't have any trouble removing the ACP empties from the cylinder using just my fingers, but getting the brass out of the clips can be a real PITA. Of course, the Auto Rim is just like any other rimmed revolver brass, easy to extract in the normal fashion, but not nearly so easy to come by and factory loaded rounds are not generally available.
When we're just plinking or doing informal target practice, we use the ACP without the clips. In the few IPSC or IDPA matches that he's shot with the revolver, we use ACP loaded into full moon clips. Half moon clips and the Auto Rim brass are, IMHO, not worth the bother or expense.