I have the 4-5/8" barrel Single Six with both .22LR & .22Mag cylinders. Can't imagine a more 'fun gun' to shoot when I want to work on sight alignment, trigger contol, etc. Mine is the 50th anniversary edition, with fixed sights.
Could be used for small game, squirrels, rabbits, etc.
.22Mag is louder than you might expect from a rimfire revolver, though..