If it headspaces on the case mouth like most other semi-auto caliber revolvers, then one could conceivably fire the revolver without moonclips though the individual cases would have to be plucked/poked out of the chambers since the extractor would have nothing to bear against.
If this is the case, one could get around the bulkiness of moonclips by simply carrying the gun with a moonclip in it and a reload in a small, single-stack semi-auto magazine. When reloading, you'd simply eject the moonclip and thumb the individual rounds out of the magazine into the chambers. Of course, you'd only have one practical reload, but most people carrying a gun of this type aren't likely to carry more than one reload anyway.
I could see where a 9mm LCR might be appealing to someone who prefers a revolver but does not handload because 9mm ammo is substantially cheaper than .38 Special or .357 Magnum. I could also see it being appealing to someone who is already set up to reload 9mm and doesn't want to have to set up for another caliber. That being said, I doubt this will be a big seller simply because 9mm revolvers have been tried at various times by Ruger, S&W, Taurus, and Charter Arms and they just never seem to gain widespread popularity (the only semi-auto cartridge that's ever managed to do that in a revolver seems to be .45 ACP).