I don't know why everyone seems to focus so much on the 300gr, I've never run into anything a 250gr wouldn't handle when loaded to a suitable velocity. But if that floats your boat, go right ahead.
I tried a number of hot loads back when I first got mine (1983) back before the 300gr became common, my heaviest was the 260gr jacketed slugs, and some loaded were more than just "Ruger only". Gun held up fine, I didn't.
Settled on a 250gr SWC (hardcast) and a load that goes just a hair under 1100fps in my 7.5". Not too bad to shoot, a couple boxes in an afternoon is a pleasant thing. Not like the real heavy loads, where I am pretty spent after a couple cylinders, or three...
There are loads out there that are not for even the tank strong Rugers. Some are just too hot (loads for rifles), and some are too long loaded for the cylinder of that particular gun.
Loads in the classic factory range are easy to shoot all day. Loads at the top end of hot for the Colt revolvers aren't bad and have plenty of power for lots of uses. Really heavy loads have the power for nearly anything, but aren't fun for plinking or casual use, and the Blackhawk is such a fun gun, if you're anything at all like my, you'll want to do a bunch of that.
One great thing about the Blackhawk is the adjustable sights. When you find you desired heavy load, zero for it, and then adjust to your casual use load and write down the direction and number of clicks to get back to the other load 's zero. You can't do that with a Colt or a Vaquero.....