I don't have a Ruger American in 223, but after playing with my wife's Ruger Precision in 6.5 CM, I was impressed.
I heard good things about the Ruger American Predator so I thought it might be a nice "light rifle" for deer/antelope, and of course it had to be a 6.5 CM.
I had a variety of bullets so after getting it sighted in I decided to see what difference the bullets would make on the zero.
I loaded a 140 A-Max with H4350, an 142 Hornady with H4350 and a Nosler 142 Accurbond with Win 760 (41,7 grns. in each case, including the 760).
It all shot the same spot.
The only modifications I did to the rifle, was a muzzle brake, a Vortex Crossfire II (6X24) and of course a sling.
I hate to say this being a Model 70 Winchester guy, but I don't think you could find a better out of the box light weight hunting rifle.
You may ask about the brake on the 6.5. After shooting wife's RPR at 10+ pounds, going to the 6.5 lb. Ruger American, a brake made a big difference.
I guess you an say it worked. It managed to gather a couple antelope on opening day.
I know most people who know, say the H4350 is the "go to" powder for the 6.5 CM but I found, in both of our 6.5s 760 works as well, plus you don't have to weight each charge, it meters so well. That saves a lot of time if you two rifles to feed.