Dead is dead, yes, but then there's life and death past 300 yards, too!
Think I read somewhere around these forums a couple days ago where somebody dropped a critter out past 400 yards, I think they were using a 7mm STW. I've prairie dogged out around 400 with my 6.5-06, and shot tactical courses out to 1000 yards with the same rifle, but I'm currently building a 6.5-300 Weatherby Magnum for thumping things way out there.