The chances of a revolver crapping out RIGHT when you need it is extremely small.
It can't have a feeding or ejection problem while you are shooting it, those are taken care of before and after the festivities. And, that is where an auto can fail. It can jam on round one-two-three etc. (of course, an auto may jam on round 13 out of the same magazine..so, you are already ahead of the revolver after TWO reloads. During the reload, the revolver can have a problem. Case slips under the star, grit under the star, short stroke of the ejector rod.)
It doesn't care if you have a crappy grip, upside down or sideways.
IF it worked the last time you pulled the trigger and, if its clean, the odds are astronomically high that it will fire the next time you pull the trigger. The majority of revolver problems are a cumulative effect of shooting it, getting dirty, things unscrewing etc.
That said, a part can break at any given moment. That can happen to any mechanical device. The odds of that happening during the six rounds you need to defend yourself? Again, pretty remote.