If you are looking to improve revolver accuracy, you pretty much do best to follow the trail blazed by revolver smiths of yore, when revolvers were still the top competitive bull's-eye handguns. All chambers were reamed to match each other's shapes, and so the throat was at least 0.001" over the barrel groove diameter (and lead bullets were sized to match the throats). The cylinder bolt or lock is shimmed or ground as needed, so the chambers line up perfectly with the bore and have no offset. Any bore constrictions (common where the barrel screws into the frame) were lapped out. A proper trigger job was done without over-lightening the springs.
It's much bother, but once you have that done, differences caused by ammunition should become much more apparent and may guide your loading practices.