New in the box or used and abused, open EVERYTHING! Thats just basic safety, after all. Personally, once I'm certain its not loaded, I do a basic function check, although I do avoid dry firing the gun in the shop, without permission.
Every gun maker has less than perfect examples get out the door. What matters most is that they stand behind their products and treat you right.
Yes, it is frustrating, we pay a lot of money (especially for a high end gun), and expect a good product. Most of the time, we get it. But when we don't, we shouldn't give up on the company, until they prove themselves undeserving of our business.
I've owned dozens of Remingtons (along with other brands), and I'm sure if I get enough, sooner or later, I'll get a bad one, maybe even NIB. If/when that happens, I'll let Remington (or who ever) make it right. I'm betting they will, although it may take longer than I would like, especially during the holiday season.