I've never used Rem Moisture Guard or any other silicon wipe. I do keep my guns (the ones that aren't loaded for EDC or HD) in a safe with desiccant packages. Thus far I haven't had any rust on my guns.
I abuse my guns in that I shoot them regardless of weather. Rain, snow, sun, cold, hot, dry, humid etc. If its range day and range time I'm on the range shooting.
If my guns got wet I bring them home, dry them, clean them and lube them then put them away where they belong.
I personally believe that with proper and regular care of your firearms you don't need all these silicon wipes, moisture guard etc.
Of course I could be way off base and I just happen to get lucky with my guns not developing rust.