re-chambering

I have the opportunity to get a very nice rifle in 375 wby. not one of my prefered calibers. can i rechamber it to 375 h and h, or even 378 wby, or any thing else?
 
It can probably be rechambered for the even larger .378 (.375") Weatherby, if the action and boltface can handle the larger cartridge - at an even greater cost in self-abuse from the recoil.

That is why there are so many used big magnums F/S, that have "only been shot a few times", and have an almost-full box of ammo to go with them.

If the rifle is nice, AND it can be had cheaply enough, I would rebarrel it to another cartridge liked better, that has the same size case head (300/7mm Mag ?)

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