I've got an early Ruger 77 with a 10 twist barrel that I picked up in '08 at garage-sale prices. I had never played with the .25-06 so I ordered some brass and some 117 Gameking bullets. My very first handload for that rifle, 50.0 grains of Reloder 22 went inside an inch at 100 yards and the chronograph showed a velocity of just over 2900 fps. That was good enough for me, and I said the heck with load development.
I've since passed that rifle along to a son, who normally shoots a heavy barreled 7mm magnum. He tell me that while he loves his heavy rifle, that the more he shoots the .25-06 the more he likes it.