Before giving a blanket "sure", what do you mean by "regular 22"
Mal is dead on...just keep the camber clean. I've fired s/l/and lr in weapons chambered for LR with no problems...just have to make sure you clean the chamber after firing the shorter rounds...or there won't be room for the LR to fully chamber.but it's not an altogether bad idea as long as you add some chamber cleaning to your routine after firing a bunch of them.