Right now, the Python is temporarily out of production so new machinery can be installed.
Apparently, the Custom Shop will assemble you a new Python from parts, until regular production starts again.
The Colt Custom Shop is world famous.
From the very beginning in the 1840's, Colt would modify a Colt firearm anyway the customer wanted.
Some Custom Shop alterations included:
Special, non-standard barrel lengths, or thicknesses.
Custom engraving and inlay work with gold, silver, or precious stones.
Custom grips of fancy wood, ivory, or other materials.
In short, anything you wanted that you could pay for.
Today, the Custom Shop still does true custom work on Colt firearms.
Although, the Custom Shop catalog lists mostly engraving and finishing on the Single Action Army, and similar work on other Colt guns, Colt will still do true custom work of about any sort you can pay for.
They also specialize in restoring and refinishing Colt firearms.
For instance, if you have a Colt Trooper or Government Model pistol with a standard blue job, they can refinish it with a Python-quality blue job.
In short, what they can do is limited only by your imagination and wallet.