I generally reduce the volume of equivalent loads of Pyrodex RS by 10% if switching to Pyrodex P, i.e. - load 90 grains of P instead of 100 of RS.
But IMO a gun would need to be in
very marginal condition safety wise for P to create a risky situation. Not that it couldn't happen with a very old or worn out gun but the warning seems to be written by lawyers for product liability reasons.
For practical purposes though the volume is reduced for velocity reasons.
I personally wouldn't worry about mixing the two granulations to experiment with mixed loads, but taking the warning into consideration and doing so only at the user's own risk of course.
I think this because even a container of black powder contains different granulations in it. There's a percentage of ffffg in every container of any granulation of black powder, and that percentage can be considerable. So the uniformity of the granulation of black powder is not nearly as consistent as Pyrodex P seems to be, which is very uniform.
Since Pyrodex is said to be a direct replacement for black powder, IMO the warning is something to be aware of but not something to be overly concerned about, at least not anymore than if switching between Goex black powder and Swiss black powder for instance.