Welcome to TFL, sandhusant!
sandhusant said:
I would like to have a pistol with zero issues meaning 100 percent reliable at all times.
That's what we all want. Unfortunately, as others pointed out, all pistols have a failure rate. You won't know, and can't know, how reliable a particular model is and, even if you did, you can't know how a reliable a particular pistol is without a little work on your part. You'll need to learn to operate the gun safely, what kinds of ammo it likes, and how to maintain it.
sandhusant said:
My reason for wanting one is for home defense, range and concealed carry. I have shot pistols only a few times.
Given these parameters, I'm going to suggest a mid-sized pistol in 9mm. That's a field that's very crowded with good pistols, and 9mm is going to be the cheapest centerfire ammo around. (Mind you, I still suggest a .22 for learning to shoot, but they're not recommended for defensive purposes.)
Here's a short list of mid-sized 9mm pistols that I've seen recommended here and on other gun sites frequently over the past handful of years:
S&W M&P 9c
Ruger SR9c
Glock 19
Springfield Armory XD and XDm
CZ (someone help me with models here)
Various 1911s in 9mm
Sig Sauer (again, I need help with models)
Most (but not all) of the above are striker-fired. Do you know if you want a striker or hammer? What is your budget? Answering these questions will help us help you.