for decades the go to powder for the .243 was 4350. Ed matunis referred to it as the "only correct powder". a 100 grain bullet can reach about 3,000 fps, and in my testing it was the absolute best accuracy compared to any other load. the load fills the case to a few mm. It is not only highly accurate in 100, I also had great results with nosler 60 gr (iirc) HP. Yes, it uses a bit more powder, iirc over 40 grains, but the sierra btsp at 45 (iirc) chronographed at 3k, gave accuracy about MOA at every shooting session, and never showed pressure signs.
You'll obviously get other opinions, but "camming over" is unnecessary and IMO can eventually compromise the bearings of the machine, or cause other problems. As long as your die body is fully in contact with the shell holder, no matter how much harder you press on it, it's not going to change anything in the eventual sizing. Of course, it would take a machinist with a micrometer set to confirm that absolutely. I'd just stop doing it.
I think that brass is too cheap to take any risks. If you are pressing your loads to the point that you got a genuine pressure ring, that brass will be compromised when you continue to use identical loads. I have just recently begun to reload again, after several years of not shooting at all due to health issues. I dumped hundreds of rounds of rifle brass because I could not positively identify which rifle I had used them in, how many loadings, etc. I will also be dumping the brass from all loaded ammo as I fire it. Yes, I have hundreds of dollars in future costs to restore my full complement of ammo.
IMO:
dump the brass. Start with new brass. Look at another powder. use a slow powder such as 4350 or another in that same category, stick ball, whatever. It is traditionally held that most powders function best when the case is almost full; it allows for more consistent ignition. This does not mean that compressed loads aren't efficient, the consistent ignition is still there. Pressures that are position sensitive will be, as stated, position sensitive, and may cause erratic ignition if the case has a lot of air space.
You failed to mention what rifle you use, full length vs neck only dies, and other things that will have bearing. A bolt rifle neck sized is going to perform very differently from a semi rifle that is full length resized every time to allow easy chambering,