In theory....
Humidity and heat can effect the performance of powder. But, in practice, provided the powder is in its original container, I have had cans for more than 25 years. IMR4198 - It's been in storage [non-climate controlled], stored in my basement [high humidity levels in summer], traveled to TX, FL and now the NE. Works fine.
If you throw your powder, you will see weight discrepancies from season to season, but heavier loads [with the same volume] are so due to moisture, which lowers the performance somewhat. This is why it is important to understand the area from which a person lives/shoots if you are taking loading information from them.
It would be extremely difficult to ruin powder if in the original container. But, humidity levels during reloading might make long term consistency more difficult.