I carry one of two different caliber pieces depending on clothes, temperature, etc. Both are DAO so there is no difference in "operation," a very important consideration. I practice with both of these averaging at least once a week, alternating between calibers. One is 9mm P-11 and the other a 32cal P-32. Both have been tweeked by me for optimal performance and reliability. I have considered getting a 1911, a Glock, a Sig, etc. but since I can shoot with either of these well, to have to deal with the "transition" between actions, I came to the conclusion that it wasn't worth it. I may not be a match winning competitor or shoot 1" groups, but you would not want to be on the receiving end if I had to "open up" if the "fit hit the shan" and lives were at stake. No matter which one I carry, the operation is identical. I don't have to stop and think "Ok, what am I carrying today - action?, operation?, etc.
Practice, practice, practice - with what you carry. The more you reduce the variables, the more effective you will be when called into action. (IM-NS-HO)