No problem. This is from Buffalo Bore's web site:
"Heavy .45 Colt +P - 325 gr. L.B.T.-L.F.N.(1,325fps/M.E.1,267 ft.lbs.) - 20 Round Box
These Heavy .45 Colt +P loads are safe in all LARGE FRAME Ruger revolvers.
(includes Blackhawk, Super Blackhawk, all pre-2005 Vaquero, Bisley, Redhawk)
These Heavy .45 Colt +P loads are NOT intended for the New Model Vaquero (small frame).
These loads are also safe in all modern Model 1892 leverguns
as well as all Winchester & Marlin 1894's"