Savagetroll,
Understand that +P is a peak pressure rating. It will have SAAMI recommended velocities for different bullet weights, but the powder that works best will change with the bullet weight and with barrel length if you are working with very short barrels. In QuickLOAD, Unique is at least near the top of the list with most all bullet weights, so if you want just one powder to experiment with for a lot of bullet weights, that would be my choice. The other powders mentioned will beat it with some bullet weights, but not all.