Robert M Boren Sr, . . .
I have owned the Python, Anaconda, Super Blackhawk, Blackhawk, and Super Redhawk.
The Python has incrementally the better trigger feel, and even though it was only a 4 in barrel, . . . in an indoor range, 50 ft targets (several years younger also I might mention), . . . I consistently dropped 10 out of 10 in the black, if not in the 9 or better rings.
The Anaconda probably came in a close second for accuracy. I did not keep it though, as I have a weakend right wrist, and half a box of full house .44's was about all I could stand. I traded it for the Super Redhawk which has more of an "up and back" recoil, . . . the Anaconda was just straight back for me. I can shoot a full box of .44's in the Super Redhawk. I believe it is a bit heavier also (though I never weighed them).
The Super Redhawk shoots 3 inch groups at 50 yards, open sights, sitting rest. I could do just a bit better with the Colt.
Conclusion, . . . get the Anaconda, it is one fine firearm, . . . if I had it to do over again, I would probably have kept it just for plinking, . . . wasn't thinking when the offer came.
May God bless,
Dwight