I can't speak to the efficacy of the Noslers, but they have always been very accurate in my rifles. However, I was blessed with the rare recovery of a Barnes XLC this year I fired out of my .308 Weatherby. I took the bullet out of a very large cow elk.
She was running full speed from right to left, and the bullet entered about 6" behind her left front shoulder. Shot was about 50 yards. She was quartering away when I hit her, and the bullet destroyed the near lung, traversed her chest, destroyed the far lung and lodged in her neck. I'm not sure how far the bullet actually travelled, but it must have been a good 22-26" of elk chest and flesh, maybe more. Load was 180gr travelling at about 2650fps, using 44gr of 748.
She dropped in a heap and was suffocating when I came up to her. A 10mm 135gr Nosler JHP (at 1450 fps - a great
coupe de gras load) to the noggin ended it humanely. After we gutted her, we noticed her esophagus was completely filled with pink, foamy blood. She was done.
This Barnes XLC did a serious number on her, expanded to .63, and retained weight was 179.6gr - 100%. Gotta love it.
Tom