M: sort of wish you could expand on all thing things you want to do, might help with some suggestions.
This is just my opinion but the Uberti- those guns are mostly for guys that want something historically accurate, as far as details- like the firing pin in the hammer rather than a transfer bar. For cowboy action shooting, etc the guns are fine. HOWEVER as far as top quality. The Older S & W's were the best- not as sure about the modern stuff. On the old S & W every part, even the bolts, were made at the factory and the steel was the best, the frame is smaller than the Ruger but Ruger uses investment casting and needs more metal. Ruger is a quality firearm and close behind the S & W. Either one is a top choice.
Just to make sure you are aware of the 45 Colt/44 Magnum situation. On the same frame the issue is not the frame but the cylinder. On the larger Colt 45 the holes for the shells are obviously larger which means the metal from the hole/chamber to the outside of the cylinder is less. That is the primary reason you cannot hot load a Colt 45 up to 44 Magnum levels.
The jury is out on the 44 Magnum. I stayed away from it for a while because of all the press about recoil When I finally got around to it I was sort of surprised to say the least.
"This isn't so bad"
" No, not bad at all"
" Maybe I'll try with one hand"
" One hand is sort of heavy but not that bad"
That's with the 6 1/2" barrel, the 4" kicks harder.
If you shoot as 45 Gvt and never really notice any recoil, then the 44 mag will not be an issue. There are far more powerful handgun rounds these days than the 44 mag.