I used to have a Blackhawk, and they are good, and, with their adjustable sights they are so much easier to sight-in than the fixed-sight Vaquero. Plus you can change the settings for different loads. That being said, I actually prefer the Vaquero with its cleaner lines and smoother handling qualities. Yeah, it can be tricky to get them shooting where you want them to. And, once you have it sighted for a particular load, you are stuck with it the way it is. So you have to find out what you and your revolver both really, really, like, and quit fooling around with something else. Did you say which caliber you bought?
Now, what I have found with my 4-5/8" barreled Vaquero in 45 Colt, is that it doesn't matter much, if at all, if I am using a high velocity or low velocity load, or what powder I use; almost all loads shoot to the same point of impact at 25 yards, as long as the bullet weight is the same, or very nearly so. I prefer home-cast, 255 grain bullets, but 250 grain jacketed bullets will hit in the same place. 800 fps or 1200 fps, the only difference is power, recoil and terminal characteristics of the bullet. Lighter bullets impact lower and heavier bullets hit higher. So I suggest you choose one bullet weight and commit to it. You will need to file your front sight to raise point of impact, but be careful not to take too much off at once. It's a lot easier to take more metal off than to put it back on.