The general consensus on the Colt Forum is that the New Python is actually superior to the old one in many respects.
It has a better DA trigger then the original, but the SA is not as good.
Heffron Gunsmithing is doing trigger jobs on them that give a DA/SA better then the original Python.
It's far smoother inside then any of the old Colt's.
The action is an all-new transfer bar safety-ignition system, but still has the old Colt "Bank Vault" lock up of the cylinder.
Accuracy as as good, and in many cases better then the original.
The action is stronger and isn't going to have any issues with timing.
Fit and finish is exceptionable.
One down check is the new rear sight.
It doesn't have click adjustments for windage.
You loosen a a small Allen head screw, then turn another screw to move windage, then you have to tighten the first screw.
Some people have had the small Allen screw back out and get lost.
They recommend putting a tiny drop of Loctite Blue on the screw.
New screws can be bought in a good hardware store.
To be fair, most revolver users sight in a new revolver and never change the rear sight settings again.
Most buyers consider the New Python to be the best DA revolver currently made in America.