Weatherby would be my first choice due to the sub MOA accuracy guarantee. Ruger would be my second choice. Durable, fairly accurate, good bang for your buck. I own a Ruger MKII in .270 and it's a great gun, but the sub MOA guarantee from Weatherby is hard to beat, and both rifles are priced similarly, if I am not mistake.
It's also worth mentioning that the Weatherby Vanguard 2 is made in Japan and Rugers are made in the US, if that stuff matters to you. It's probably how Weatherby gets away making a sub MOA gun for about the same price as the Ruger, which are also capable of shooting sub MOA, but it's less likely to do so with factory ammo. Ruger has no accuracy guarantee, other than if the rifle can't shoot for spit, they'll take it back and look at it.