IF you had a 'conical' that you could load straight, perhaps, but unless you're into long range shooting with a handgun, it's unlikely the difference would be noticeable.
The issue with 'conicals' in any revolver is being able to get the long axis aligned with the chamber and barrel centerline. Projectiles in a cap and ball revolver need to be swaged into the chamber to prevent flash over, aka chain fires. I don't know of any 'conical' shaped round that lends itself to this swaging action; they all tend to get 'tipped over' on loading and are thus no longer efficient aerodynamically on leaving the barrel.