Fired from a 50 Savage ML10, I can tell you that the 45cal 300gr Barnes Original bullet makes a hole in deer like nothing else that I've ever seen.
Honest to God, 4 inch exit hole. Not just 4 inches of blood around a 1 inch hole. A complete, blown to shreds, 4 inch hole.
The exit was through the shoulder, but I've seen that many, many times before with nothing spectacular to say about. This deer was literally missing a 4 inch circle in it's shoulder.