Trajectory does not matter, the targets are at a known distance. You want accuracy and mild recoil. The old standby is the 308, which is what I use with the 168 grain Hornady match BTHP at 2600 FPS muzzle velocity. You can find the trajectory right in the Horandy reloading manual and calculate your scope settings withour firing a shot. Go to the range to confirm the zeros. The starting place is to determine your 200 meter zero. Set your scope target turret to "0" for the 200 meter zero. I recall that I click up to 3.5, 7 and 13 MOA for the targets at 300, 385 and 500 meters.
After using the 308, shooters flocked to the 7mm-08 and now most shooters would build a new rifle in 260 REM or 6.5 -08. The 6.5 Swede works, too. The 243 will ding rams and leave them standing.
My rifle is the REM PSS 308, a rifle like a Varmint Synthetic. I just made weight at 10 lb. and 2 oz. with a Leupold 24x scope by removing the steel magazine follower and swivel stud from the rifle. The barrel on this rifle is 24".