I've never heard of that being done. The straighter walls of the Ackley might cause increased feed or slamfire concerns, but I don't know from experience with it. It would definitely raise gas port pressure for a given velocity simply because the larger powder quantity makes more gas. That would mean a slightly smaller gas port would likely be appropriate for it.
The op-rod in the Garand is more delicate than the system in the M14/M1A, so unless you have a vented gas cylinder plug or the Garand Gear gas cylinder plug (as you do), so you want to try to keep the gas impulse at the gas port down (approximately proportional to muzzle pressure divided by bullet velocity) for it. That means you will need a way to estimate or measure muzzle pressure, such as QuickLOAD and GRT provide (which don't agree on the value, btw, but which should give you a valid comparison as long as you stick with one of them).
If you look up
John Clark's Garand loads from the March 1986 issue of TAR, you will find bullet weights up to 200 grains. Most people loading for the Garand today find these loads scary, but I have fiddled with the gas impulse numbers using interior ballistics program estimates and found the milder middle loads for the more usual 150-175 grain bullets often produce an even higher gas impulse than warmer loads of the same powder do. This is because bullet speed increases faster with powder charge than muzzle pressure does. So the gun isn't as sensitive to warmer loads as some think, as long as the powder choice is reasonable. Increased bullet weight does increase gas impulse, though.
You will note Clark's loads all use the Federal 210M primer. I did, too, when I started loading for the gun and never had a problem. However, I wouldn't do that today due to all the slamfire reports with that primer that I've seen reported. Most now use something harder, especially the CCI #34, when available. The #34 uses a magnum primer pellet, and many find that because a lot of medium burn-rate powders leave a fair amount of empty space in the case, it can improve ignition consistency, reducing velocity variation. You would want to knock all of Clark's loads down 10% to work them up with #34 or other magnum primers in your gun today. You want to do that anyway as a matter of good practice since powder lots and manufacturing processes and burn rate controls have all changed or improved since then, and you may be loading warmer than you think by following his recipes blindly. H4895, for example, was still a repackaged surplus IMR 4895 then, I believe. The change to the Australian Extreme formulation came a few years later, and I would not treat it the same powder now.