Start with a good quality recent manufacture, .22 rimfire.
Either auto or wheelgun. This is the one thing that IMO, you'll never regret buying and keep it forever. Not to mention fun AND cheap to shoot.
If you don't want to go that way, I'd say if you wanted powerful w/ out the shock of the .44, get a full size (or for carry a 4" model) 1911 .45. I prefer Kimber, but see what's out there that YOU like. Colt, SA, STI, ECT....
Functionally they are the same pick onw you like.