Thre have been certain "standards" for decades: 130-grain for the .270, 139 or 140-grain for the 7mm and 150-grain for the .30s. For the deer-sized critters, anyhow. Heavier for elk, for probably-better penetration.
Sure, you can mess around, but it's sorta like reinventing the wheel.
The main reason I know of to load down is to reduce recoil. I figure that if you download for a doe, you might as well stay with it for a buck...