The standard Vari X III has small knobs for W and E. I believe it also has the standard reticle. The Tactical version has target knobs, no AO, and is available with a Mil Dot reticle. Both are 1" tubes. The two long range versions are 30mm tubes, have a side focus knob like the Mk IVs. One has 1/4 min adjustments (M1), the other is cammed as a BDC (M3), with the option for different calibers if memory serves me correctly.
For ease of making adjustments, I would go with the target knobs, and an AO. The problem with hunting is that you generally don't have the time to make adjustments when the animal is present.
The biggest con to the scopes is a lack of the AO on the Tactical model, and IMO the BDC knob on the M3 scope. I would probably choose the M1 version. A bigger tube, sturdy, just make sure to find mounts for a 30mm, which should not be a problem.
Any of the 3.5x10s will reach out to those ranges you asked about, I think what it might come down to is which model you are most comfortable with.
I use the Tactical model and am happy with it, it certainly works for 400 and 500 yards.