Depends on how you hold your gun. I think they would be fine. I would go to a fun store and hold one that already has them installed, before spending that spending that kind of money.
I'd bet there are lefties here that will be along shortly with a definitive answer.
If they don't work for left handed shooters Crimson Trace is losing a great number of potential customers.
I use Crimson Trace laser grips on my XD-9, and shoot either handed, works as well left as right handed shooting. Actually, since the laser is on the right side of the grip, it works better for a lefty.
I am left handed and I have the Crimson Trace lasergrips on every one of my handguns, even the revolvers. I like having the laser on the right side and I agree that it actually works better for a left handed shooter to have the laser on the right. I think the set-up works even better for us than it does for the right-handed shooters.
