I have Crimson Trace laser grips on three handguns, and would not buy a handgun that CT did not make a set of grips for. I am that sold on them.
If I were into bullseye, as I was decades ago, it would be different. For that, adjustable iron sights are the way to go because the red dot won't make it out to fifty yards in the noonday sun. But at my age, that is history. My use for them is home/self defense, and there Crimson Trace grips, with their excellent, quite instinctive actuators, really shine.
Cordially, Jack