Most substitutes are the same BUT a few aren`t. As Hawg mentioned prior Triple Seven(777) is hotter and has to be measured according. Its a good powder. I`ve used American Pioneer, Clean Shot and Shockeys Gold with good results. I`ve heard Blackhorn is really good but make sure your rifle is safe to shoot it. There are many to choose from. Again, make sure your rifle can shoot them and follow measuring instructions on can. Also, when buying your possible`s,its a good idea(as mentioned earlier) to buy a powder flask and fill flask with amount of powder you think you`ll use in a range session. That just keeps you from opening your main jug of powder everytime you load. Moisture is powders enemy. Another point: if hunting in rainy condtition, after your loaded(WITH PRIMER OFF NIPPLE) put a piece of electrical tape over muzzle. Keeps rain out and won`t affect shot.