I was concerned about that too. My frame has likely been exposed to: Outer's gun oil, Outer's nitro solvent, Eezox, Ballistol, Clenzoil, Rem oil, over the last few years. No flaking of the clear coat. HOWEVER, I don't generally apply them to the frame, only the barrel and cylinder. I rub the frame clean with a rag - which usually doesn't get fouled up anyways except by the corners of the top strap and around the forcing cone.